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Irene M Ghobrial Selected Research

Immunoglobulin M (IgM)

12/2022Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenström macroglobulinemia.
10/2021Phase 1 study of ibrutinib and the CXCR4 antagonist ulocuplumab in CXCR4-mutated Waldenström macroglobulinemia.
1/2021Long-Term Follow-Up of Ibrutinib Monotherapy in Symptomatic, Previously Treated Patients With Waldenström Macroglobulinemia.
1/2019Progression Risk Stratification of Asymptomatic Waldenström Macroglobulinemia.
1/2018Profiling of circulating exosomal miRNAs in patients with Waldenström Macroglobulinemia.
8/2017A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation.
8/2017IgM myeloma: A multicenter retrospective study of 134 patients.
5/2017Prospective, Multicenter Clinical Trial of Everolimus as Primary Therapy in Waldenstrom Macroglobulinemia (WMCTG 09-214).
1/2016Epigenomics in Waldenstrom's macroglobulinaemia.
2/2015Extramedullary Waldenström macroglobulinemia.
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Irene M Ghobrial Research Topics

Disease

83Multiple Myeloma
12/2022 - 09/2003
81Neoplasms (Cancer)
05/2022 - 10/2002
71Waldenstrom Macroglobulinemia (Macroglobulinemia)
10/2022 - 11/2003
14Paraproteinemias (Monoclonal Gammopathy)
05/2022 - 09/2008
12Disease Progression
01/2022 - 02/2004
11Lymphoma (Lymphomas)
05/2017 - 02/2004
10B-Cell Lymphoma (Lymphoma, B Cell)
01/2018 - 05/2008
10Neoplasm Metastasis (Metastasis)
07/2015 - 01/2011
9Hematologic Neoplasms (Hematological Malignancy)
05/2022 - 07/2011
9Lymphoproliferative Disorders (Lymphoproliferative Disorder)
08/2014 - 12/2003
7Non-Hodgkin Lymphoma (Lymphosarcoma)
12/2022 - 01/2009
7Anemia
08/2017 - 10/2008
6Thrombocytopenia (Thrombopenia)
06/2016 - 04/2006
5Monoclonal Gammopathy of Undetermined Significance
12/2022 - 01/2011
5Fatigue
01/2022 - 09/2003
5Residual Neoplasm
10/2021 - 01/2011
5Smoldering Multiple Myeloma
01/2020 - 10/2014
5Cryoglobulinemia
01/2015 - 12/2004
4Inflammation (Inflammations)
01/2022 - 01/2013
4Bone Marrow Diseases (Bone Marrow Disease)
10/2021 - 08/2009
4Neutropenia
06/2016 - 03/2010
4Cytopenia
08/2014 - 06/2008
4Carcinogenesis
04/2014 - 11/2010
3Leukemia
01/2019 - 01/2009
3Hypoxia (Hypoxemia)
01/2019 - 06/2012
3Peripheral Nervous System Diseases (PNS Diseases)
07/2014 - 09/2003
2Cardiac Arrhythmias (Arrythmia)
01/2021 - 03/2011
2Insulin Resistance
10/2020 - 06/2019
2Hyperinsulinism (Hyperinsulinemia)
10/2020 - 06/2019
2Bone Diseases (Bone Disease)
01/2018 - 01/2012
2Circulating Neoplastic Cells
01/2017 - 01/2011
2Breast Neoplasms (Breast Cancer)
01/2017 - 03/2014
2Exanthema (Rash)
06/2016 - 09/2003
2Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)
01/2015 - 01/2009
2Septic Shock (Toxic Shock Syndrome)
09/2012 - 03/2011
2B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
08/2012 - 03/2004
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
01/2012 - 05/2005
2Infections
03/2011 - 12/2004

Drug/Important Bio-Agent (IBA)

40Immunoglobulin M (IgM)IBA
12/2022 - 11/2003
30Bortezomib (Velcade)FDA Link
01/2022 - 09/2008
18Proteins (Proteins, Gene)FDA Link
05/2022 - 06/2004
17MicroRNAs (MicroRNA)IBA
01/2018 - 04/2009
15Lenalidomide (CC 5013)FDA Link
01/2022 - 09/2008
11Dexamethasone (Maxidex)FDA LinkGeneric
01/2022 - 08/2009
9Pharmaceutical PreparationsIBA
10/2021 - 01/2011
9Rituximab (Mabthera)FDA Link
07/2014 - 02/2004
7Biomarkers (Surrogate Marker)IBA
10/2021 - 02/2011
7EverolimusFDA Link
05/2017 - 03/2010
6TOR Serine-Threonine KinasesIBA
09/2015 - 11/2006
5Thalidomide (Thalomid)FDA Link
02/2013 - 09/2003
5Proteasome Endopeptidase Complex (Proteasome)IBA
04/2011 - 05/2008
4ibrutinibIBA
10/2021 - 11/2016
4RNA (Ribonucleic Acid)IBA
01/2021 - 01/2016
4Proteasome InhibitorsIBA
01/2019 - 05/2009
4Mechanistic Target of Rapamycin Complex 1IBA
05/2017 - 12/2011
4Melphalan (Alkeran)FDA LinkGeneric
05/2015 - 03/2007
4Immunoglobulins (Immunoglobulin)IBA
01/2014 - 06/2008
4Antineoplastic Agents (Antineoplastics)IBA
04/2011 - 03/2004
3Blood Proteins (Serum Proteins)IBA
05/2022 - 04/2012
3Hemoglobins (Hemoglobin)IBA
10/2021 - 05/2017
3DNA (Deoxyribonucleic Acid)IBA
01/2021 - 01/2014
3OligonucleotidesIBA
01/2018 - 08/2012
3Diphosphonates (Bisphosphonates)IBA
01/2017 - 01/2012
3Biological ProductsIBA
01/2016 - 01/2014
3LigandsIBA
07/2015 - 02/2012
3carfilzomibIBA
06/2015 - 04/2011
3CytokinesIBA
10/2014 - 09/2007
3Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
06/2014 - 11/2006
3enzastaurinIBA
09/2012 - 06/2007
3perifosineIBA
11/2011 - 12/2007
3Histones (Histone)IBA
02/2011 - 09/2010
3Cytotoxins (Cytolysins)IBA
04/2009 - 05/2005
2Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2022 - 11/2020
2ulocuplumabIBA
10/2021 - 01/2020
2Chimeric Antigen ReceptorsIBA
10/2021 - 06/2019
2plerixaforFDA Link
11/2019 - 04/2009
2ResveratrolIBA
08/2019 - 03/2008
2Immune Checkpoint InhibitorsIBA
06/2019 - 01/2017
2locked nucleic acidIBA
01/2018 - 08/2012
2Monoclonal AntibodiesIBA
01/2018 - 06/2014
2Immunoglobulin G (IgG)IBA
11/2016 - 07/2014
2CreatinineIBA
06/2016 - 01/2009
2IntegrinsIBA
07/2015 - 06/2011
2ParaproteinsIBA
02/2015 - 04/2009
2Cadherins (E-Cadherin)IBA
02/2015 - 06/2012
2ChemokinesIBA
10/2014 - 10/2006
2Zoledronic Acid (Zometa)FDA Link
08/2014 - 01/2012
2Immunoglobulin A (IgA)IBA
07/2014 - 01/2009
2Messenger RNA (mRNA)IBA
01/2014 - 06/2011
2MTOR InhibitorsIBA
12/2012 - 03/2011
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2012 - 04/2009
2Sirolimus (Rapamycin)FDA Link
12/2011 - 11/2006
2ChymotrypsinFDA Link
04/2011 - 05/2010

Therapy/Procedure

79Therapeutics
01/2022 - 10/2002
7Drug Therapy (Chemotherapy)
12/2020 - 02/2004
6Stem Cell Transplantation
12/2022 - 06/2004
3Transplantation
01/2022 - 01/2005
2Dietary Approaches To Stop Hypertension
10/2020 - 06/2019
2Mediterranean Diet
10/2020 - 06/2019
2Autologous Transplantation
08/2014 - 01/2009